Oral sodium bicarbonate protocol for high-dose methotrexate urine alkalinization: A pediatric experience.

Mark DiachinskyTracey TranJennifer JuppKrista McKinnon

Published in: Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners (2020)

Oral NaHCO3 with LR is a feasible alternative for urine alkalinization. The total dose of NaHCO3 utilized was lower in the oral cohort, with no additional delays in clearance.

Keyphrases

high dose
randomized controlled trial
low dose
stem cell transplantation