Proteomic analysis of infected root canals with apical periodontitis in patients with type 2 diabetes mellitus: A cross-sectional study.
Caroline LoureiroMarília Afonso Rabelo BuzalafJuliano Pelim PessanTalita Mendes Oliveira VenturaMarília Afonso Rabelo BuzalafAna Paula Fernandes RibeiroRogério de Castilho JacintoPublished in: International endodontic journal (2022)
Quantitative differences were demonstrated in the expression of proteins common to diabetic and control groups, mainly related to immune response, oxidative stress, apoptosis and proteolysis. These findings revealed biological pathways that provide the basis to support clinical findings on the relationship between AP and T2DM.
Keyphrases
- oxidative stress
- immune response
- poor prognosis
- type diabetes
- dna damage
- endoplasmic reticulum stress
- physical activity
- transcription factor
- high resolution
- single cell
- induced apoptosis
- diabetic rats
- ischemia reperfusion injury
- dendritic cells
- risk factors
- binding protein
- toll like receptor
- adipose tissue
- glycemic control
- pi k akt