FBL Promotes LPS-Induced Neuroinflammation by Activating the NF-κB Signaling Pathway.
Zhuoyuan ZhangDan LiuRui LvHaoyan ZhaoTianjing LiYutao HuangZhicheng TianXiangyu GaoPeng LuoXin LiPublished in: Journal of inflammation research (2024)
LPS induced the expression of FBL in HT22 cells through the RAS/MAPK signaling pathway, and FBL further activated the NF-kB signaling pathway, which promoted the expression of relevant inflammatory genes and the release of cytokines. The present study reveals the mechanism by which FBL promotes neuroinflammation and offers a potential target for the treatment of neuroinflammation.
Keyphrases
- lps induced
- signaling pathway
- induced apoptosis
- pi k akt
- inflammatory response
- poor prognosis
- cell cycle arrest
- epithelial mesenchymal transition
- oxidative stress
- lipopolysaccharide induced
- binding protein
- risk assessment
- genome wide
- endoplasmic reticulum stress
- long non coding rna
- blood brain barrier
- genome wide analysis