Pneumocystis jirovecii Pneumonia in a Patient with Rheumatoid Arthritis Treated with Abatacept.
Fabio E OspinaAndrés AgualimpiaFabio Bonilla-AbadíaCarlos A CañasGabriel J TobónPublished in: Case reports in rheumatology (2014)
Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial membrane inflammation and joint cartilage destruction. Abatacept is a biologic agent that blocks the costimulation signals, preventing antigen presentation and proliferation of T lymphocytes. It is approved for the treatment of patients with RA. Pneumocystis jirovecii pneumonia (PJP) is an infectious disease complicating several immunosuppressive drugs. PJP associated with abatacept has not been reported yet in the medical literature. Various factors, such as the mechanism of action of abatacept, may contribute to predisposing to Pneumocystis jirovecii infection. In this paper, we report a patient with RA who developed PJP under abatacept treatment.
Keyphrases
- rheumatoid arthritis
- disease activity
- ankylosing spondylitis
- interstitial lung disease
- case report
- rheumatoid arthritis patients
- infectious diseases
- systematic review
- healthcare
- oxidative stress
- signaling pathway
- multiple sclerosis
- systemic lupus erythematosus
- combination therapy
- community acquired pneumonia
- mechanical ventilation