Increased OCT3 expression in adipose tissue with aging: implications for lipid turnover and insulin resistance in women.

Fozia Z AhmedMilica VranicSusanne HettyArgyri MathioudakiVagia PatsoukakiGiovanni FanniMaria João PereiraJan W Eriksson

Published in: Endocrinology (2023)

OCT3 mRNA and protein levels in SAT were increased with aging, and mRNA levels were negatively associated with markers of insulin resistance. E2 incubation downregulated OCT3 mRNA levels, which may explain lower OCT3 mRNA levels in premenopausal compared to postmenopausal women. High OCT3 mRNA and protein levels may result in increased catecholamine degradation, which may account for the reduction in adipose tissue lipolysis observed with aging.

Keyphrases

adipose tissue
postmenopausal women
insulin resistance
binding protein
optical coherence tomography
bone mineral density
diabetic retinopathy
high fat diet
polycystic ovary syndrome
metabolic syndrome
optic nerve
small molecule
skeletal muscle
protein protein
fatty acid
breast cancer risk