ERK Regulates HIF1α-Mediated Platinum Resistance by Directly Targeting PHD2 in Ovarian Cancer.

Zhuqing LiWei ZhouYi ZhangWei SunMingo M H YungJing SunJing LiChi Wei ChenZongzhu LiYunxiao MengJie ChaiYuan ZhouStephanie S LiuAnnie N Y CheungHextan Yuen-Sheung NganDavid W ChanWei ZhengWenge Zhu

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

HIF1α stabilization is regulated by TGFβ1/ERK/PHD2 axis in PROC. Hence, inhibiting TGFβ1, ERK, or HIF1α is potential strategy for treating patients with PROC.

Keyphrases

signaling pathway
pi k akt
cell proliferation
transforming growth factor
endothelial cells
epithelial mesenchymal transition