ILC3 deficiency and generalized ILC abnormalities in DOCK8-deficient patients.
Ahmet EkenMurat CanseverFatma Zehra OkusSerife ErdemErcan NainZehra Busra AzizogluYesim HalilogluMusa KarakukcuAlper OzcanOmer DeveciogluGuzide AksuZeynep Arikan AyyildizErdem TopalElif Karakoc AydinerAyca KiykimAyse MetinFunda CipeAysenur KayaHasibe ArtacIsmail ReisliSukru N GunerVedat UygunGulsun KarasuHamiyet Dönmez AltuntasHalit CanatanMohamed OukkaAhmet OzenTalal A ChatilaSevgi KelesSafa BarisEkrem ÜnalTurkan PatirogluPublished in: Allergy (2019)
DOCK8 regulates human ILC3 expansion and survival, and more globally ILC cytokine signaling and proliferation. DOCK8 deficiency leads to loss of ILC3 from peripheral blood. ILC3 deficiency may contribute to the susceptibility of DOCK8-deficient patients to infections.