Insulin-like growth factor binding protein 2 in bipolar disorder: An expression study in peripheral tissues.

Elena Milanesi Roberta Zanardini Gianluca Rosso Giuseppe Maina Alessandro Barbon Cristina Mora Alessandra Minelli Massimo Gennarelli Luisella Bocchio-Chiavetto

Published in: The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry (2017)

Our findings in peripheral tissues are consistent with previous results in the brain and support a downregulation of IGFBP2 expression that is specific for BD, suggesting a role for this protein in the alterations in neurodevelopment and neuroprotection observed in the disorder. Further studies in independent and larger cohorts are warranted to confirm the involvement of IGFBP2 in BD.

Keyphrases

binding protein
bipolar disorder
poor prognosis
gene expression
major depressive disorder
cerebral ischemia
white matter
signaling pathway
brain injury
multiple sclerosis
protein protein
subarachnoid hemorrhage
blood brain barrier