GRP78 Activity Moderation as a Therapeutic Treatment against Obesity.
Dongjin PanYunzhu YangAihua NongZhenzhou TangQingxiao LiPublished in: International journal of environmental research and public health (2022)
Glucose-regulated protein 78 (GRP78), a molecular chaperone, is overexpressed in patients suffering from obesity, fatty liver, hyperlipidemia and diabetes. GRP78, therefore, can be not only a biomarker to predict the progression and prognosis of obesity and metabolic diseases but also a potential therapeutic target for anti-obesity treatment. In this paper, GRP78 inhibitors targeting its ATPase domain have been reviewed. Small molecules and proteins that directly bind GRP78 have been described. Putative mechanisms of GRP78 in regulating lipid metabolism were also summarized so as to investigate the role of GRP78 in obesity and other related diseases and provide a theoretical basis for the development and design of anti-obesity drugs targeting GRP78.
Keyphrases
- insulin resistance
- metabolic syndrome
- endoplasmic reticulum stress
- weight loss
- type diabetes
- high fat diet induced
- weight gain
- cell surface
- cardiovascular disease
- high fat diet
- body mass index
- drug delivery
- blood pressure
- blood glucose
- glycemic control
- fatty acid
- patient reported outcomes
- physical activity
- single molecule
- amino acid
- oxidative stress
- climate change
- heat shock