SCReadCounts: estimation of cell-level SNVs expression from scRNA-seq data.
N M PrashantNawaf AlomranYu ChenHongyu LiuPavlos BousounisMercedeh MovassaghNathan EdwardsAnelia Dafinova HorvathPublished in: BMC genomics (2021)
SCReadCounts supplies a fast and efficient solution for estimation of cell-level SNV expression from scRNA-seq data. SCReadCounts enables distinguishing cells with monoallelic reference expression from those with no gene expression and is applicable to assess SNVs present in only a small proportion of the cells, such as somatic mutations in cancer.
Keyphrases
- single cell
- poor prognosis
- gene expression
- induced apoptosis
- cell cycle arrest
- rna seq
- electronic health record
- genome wide
- binding protein
- cell therapy
- big data
- dna methylation
- endoplasmic reticulum stress
- papillary thyroid
- squamous cell carcinoma
- cell proliferation
- machine learning
- bone marrow
- artificial intelligence
- data analysis