Effect of escitalopram dose and treatment duration on CSF Aβ levels in healthy older adults: A controlled clinical trial.

Yvette I ShelineB Joy SniderJoanne C BeerDarsol SeokAnne M FaganRaymond F SuckowJin-Moo LeeTeresa WaligorskaMagdalena KoreckaIrem AselciogluJohn C MorrisLeslie M ShawJohn R Cirrito

Published in: Neurology (2020)

This study provides Class II evidence that for cognitively normal older adults, escitalopram decreases CSF Aβ42.

Keyphrases

clinical trial
physical activity
major depressive disorder
cognitive decline
mild cognitive impairment
randomized controlled trial
open label
cerebrospinal fluid
study protocol
combination therapy
phase iii