Raptor and rictor expression in patients with human papillomavirus-related oropharyngeal squamous cell carcinoma.

Shunsuke KondoHitoshi HirakawaTaro IkegamiTakayuki UeharaShinya AgenaJin UezatoHidetoshi KinjyoNoritomo KiseYukashi YamashitaKatsunori TanakaNarumi HasegawaAsanori KiyunaHiroyuki MaedaMikio SuzukiAkira Gahana

Published in: BMC cancer (2021)

These results suggest that raptor and rictor have important roles in HPV-related OPSCC and that temsirolimus is a potential therapeutic agent for patients with HPV-related OPSCC. This is the first report to reveal the overexpression of raptor and rictor in HPV-related OPSCC.

Keyphrases

squamous cell carcinoma
high grade
poor prognosis
dna methylation
single cell
lymph node metastasis
drug induced
locally advanced