A Total Synthesis of Salinosporamide A.

Published in: Chemistry (Weinheim an der Bergstrasse, Germany) (2018)

Salinosporamide A is a β-lactone proteasome inhibitor currently in clinical trials for the treatment of multiple-myeloma. Herein we report a short synthesis of this small, highly functionalized, biologically important natural product that uses an oxidative radical cyclization as a key step and allows for the preparation of gram quantities of advanced synthetic intermediates.

Keyphrases

clinical trial
multiple myeloma
molecularly imprinted
gram negative
quantum dots
randomized controlled trial
combination therapy
mass spectrometry
replacement therapy
simultaneous determination
tandem mass spectrometry