A High-Content Screen for C/EBPα Expression Identifies Novel Therapeutic Agents in Dedifferentiated Liposarcoma.

Christina V Angeles Ana VelezJordan RiosBernadette LaxaDavid ShumPenelope D Ruiz Yawei Shen Irina Ostrovnaya Rodrigo Gularte-Mérida Benjamin A NacevMark A DicksonDavid ShumTomoyo OkadaSamuel Singer

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)

This high-content screen revealed potential treatments for DDLS. These include irinotecan, which induces apoptosis of DDLS cells in a C/EBPα-dependent, p53-independent manner, and should be clinically evaluated in patients with advanced DDLS.

Keyphrases

high throughput
induced apoptosis
poor prognosis
cell cycle arrest
genome wide
risk assessment
cell death
signaling pathway
binding protein
human health
dna methylation
climate change