Cancer cell-intrinsic expression of MHC II in lung cancer cell lines is actively restricted by MEK/ERK signaling and epigenetic mechanisms.

Alexander J Neuwelt Abigail K Kimball Amber M JohnsonBenjamin W ArnoldBonnie L Bullock Rachael E Kaspar Emily K KleczkoJeff W KwakMeng-Han WuLynn E HeasleyRobert C DoebeleHoward Y Li Raphael A Nemenoff Eric T Clambey

Published in: Journal for immunotherapy of cancer (2021)

These studies emphasize the active inhibitory role that epigenetic and ERK signaling cascades have in restricting cancer cell-intrinsic MHC II expression in NSCLC, and suggest that combinatorial blockade of these pathways may engender new responsiveness to checkpoint therapies.

Keyphrases

poor prognosis
pi k akt
signaling pathway
dna methylation
gene expression
cell proliferation
small cell lung cancer
dna damage
binding protein
cell cycle
long non coding rna
case control