Risk and symptoms of COVID-19 in health professionals according to baseline immune status and booster vaccination during the Delta and Omicron waves in Switzerland-A multicentre cohort study.

Baharak Babouee FlurySabine GüsewellThomas Egger Onicio LealAngela BrucherEva LemmenmeierDorette Meier KleebJ Carsten MöllerPhilip RiederMarkus RüttiHans-Ruedi SchmidReto StockerDanielle Vuichard-Gysin Benedikt J WiggliUlrike BesoldAllison J McGeerLorenz RischAndrée FriedlMatthias SchlegelStefan P Kuster Christian R Kahlert Philipp P Kohlernull null

Published in: PLoS medicine (2022)

Our data suggest that hybrid immunity and booster vaccination are associated with a reduced risk and reduced symptom number of SARS-CoV-2 infection during Delta- and Omicron-dominant periods. For previously noninfected individuals, booster vaccination might reduce the risk of symptomatic Omicron infection, although this benefit seems to wane over time.

Keyphrases

coronavirus disease
sars cov
electronic health record
respiratory syndrome coronavirus
randomized controlled trial
study protocol
machine learning
big data
deep learning
breast cancer risk