Neonatal Outcomes in Pregnant Women with Systemic Lupus Erythematosus: A 13-Year Experience in Southern Thailand.
Pattima PakhathirathienWaricha JanjindamaiSupaporn DissaneevateAnucha ThatrimontrichaiGunlawadee ManeenilPublished in: Journal of tropical pediatrics (2021)
Neonatal lupus erythematosus (NLE) is the consequence of the transplacental passage of autoantibodies to newborns during pregnancy. The clinical features of NLE infants in our study were hemolytic anemia (8%), thrombocytopenia (2.7%) and hyperbilirubinemia (5.3%). There was no neonate with a congenital complete heart block or skin lesion. We also compared the neonatal outcomes between 118 pregnant women with SLE and 264 randomly selected healthy pregnant women. Our study found that the neonates born to women with SLE increased the risk of preterm birth, low birth weight, birth asphyxia and NICU admission. Moreover, SLE disease activity and corticosteroid and azathioprine usage were associated with preterm delivery in pregnant women with SLE.
Keyphrases
- systemic lupus erythematosus
- low birth weight
- disease activity
- preterm birth
- pregnant women
- preterm infants
- human milk
- gestational age
- rheumatoid arthritis patients
- rheumatoid arthritis
- ankylosing spondylitis
- juvenile idiopathic arthritis
- heart failure
- pregnancy outcomes
- chronic kidney disease
- emergency department
- metabolic syndrome
- skeletal muscle
- adipose tissue