IFN-stimulated Gene Expression, Type 2 Inflammation, and Endoplasmic Reticulum Stress in Asthma.

Nirav R BhaktaStephanie A ChristensonSrilaxmi NerellaOwen D SolbergChristine P NguyenDavid F ChoyKyle L JungSuresh GarudadriLuke R BonserJoshua L PollackLorna T ZlockDavid J ErleCharles LangelierJoseph L DerisiJoseph R ArronJohn V FahyPrescott G Woodruff

Published in: American journal of respiratory and critical care medicine (2019)

ISG activation is prominent in asthma, independent of viral transcripts, orthogonal to type 2 inflammation, and associated with distinct clinical features. ER stress is associated with both type 2 inflammation and ISG expression.

Keyphrases

endoplasmic reticulum stress
oxidative stress
gene expression
chronic obstructive pulmonary disease
induced apoptosis
lung function
poor prognosis
sars cov
immune response
allergic rhinitis
dendritic cells
cystic fibrosis
long non coding rna