A randomized trial of the effects of COMT inhibition on subjective response to alcohol: Moderation by baseline COMT activity and mediation of alcohol self-administration.

Joseph P SchachtMatthew KubickiRaymond K Anton

Published in: Alcohol, clinical & experimental research (2023)

Tolcapone may reduce subjective response to alcohol more effectively among individuals with preexisting high COMT activity an effect that could account for the drug's reduction of alcohol consumption among these individuals.

Keyphrases

alcohol consumption
sleep quality
social support
depressive symptoms