Fatty acids metabolism affects the therapeutic effect of anti-PD-1/PD-L1 in tumor immune microenvironment in clear cell renal cell carcinoma.
Hansen LinLiangmin FuPengju LiJiangquan ZhuQuanhui XuYinghan WangMukhtar Adan MuminXinwei ZhouYuhang ChenGuannan ShuGaosheng YaoMinyu ChenJun LuLizhen ZhangYuJun LiuYiqi ZhaoJiahao BaoWei ChenJunhang LuoXiaofei LiZhen-Hua ChenJiazheng CaoPublished in: Journal of translational medicine (2023)
The study elucidates that targeting fatty acids metabolism can affect the therapeutic effect of PD-1/PD-L1 in TME and related signal pathways. The model can effectively predict the response to several treatment options, underscoring its potential clinical utility.