Combinatorial Tim-3 and PD-1 activity sustains antigen-specific Th1 cell numbers during blood-stage malaria.

Rebecca S DookieAna Villegas-MendezHans KroezeJordan R BarrettSimon J DraperBlandine M Franke-FayardChris J JanseAndrew S MacDonaldKevin N Couper

Published in: Parasite immunology (2020)

Thus, our results show that Tim-3 plays an unexpected combinatorial role with PD-1 in promoting and/ or sustaining a Th1 cell response during the early phase of blood-stage P. yoelii NL infection but combined blockade does not dramatically influence anti-parasite immunity.

Keyphrases

single cell
cell therapy
mesenchymal stem cells
toxoplasma gondii
life cycle