PDE4D mediates impaired β-adrenergic receptor signaling in the sinoatrial node in mice with hypertensive heart disease.

Tristan W DoreyMegan D McRaeDarrell D BelkeRobert A Rose

Published in: Cardiovascular research (2023)

AngII-induced hypertensive heart disease results in impaired HR responses to β-AR stimulation due to upregulation of PDE4D and reduced effects of cAMP on spontaneous AP firing in SAN myocytes.

Keyphrases

blood pressure
pulmonary hypertension
high glucose
diabetic rats
lymph node
transcription factor
poor prognosis
cell proliferation
high fat diet induced
signaling pathway
binding protein
drug induced
oxidative stress
adipose tissue
metabolic syndrome
protein kinase
wild type