Spatial Proteomics Analysis of Soft and Stiff Regions in Human Acute Arterial Thrombus.

Hongcheng MaiTianyuan ZhangTao ZhangAijun LuZhengdong WuBing YangNiu HeXiaoyan LiuChi Kwan Tsang Liangxue Lai Dan Lu

Published in: Stroke (2023)

This study demonstrates the spatially distinct composition of proteins in the stiff and soft regions of human arterial thrombi, and suggests that TGF-β1 is a key therapeutic target for promoting arterial thrombolysis.

Keyphrases

endothelial cells
induced pluripotent stem cells
pluripotent stem cells
pulmonary embolism
liver failure
intensive care unit
respiratory failure
extracorporeal membrane oxygenation
aortic dissection
hepatitis b virus
drug induced
epithelial mesenchymal transition