Specific expression of PD-L1 in RELA-fusion supratentorial ependymoma: Implications for PD-1-targeted therapy.
Davis A WittAndrew M DonsonVladimir AmaniDaniel C MoreiraBridget SanfordLindsey M HoffmanMichael H HandlerJean M Mulcahy LevyKenneth L JonesAnandani NellanNicholas K ForemanAndrea M GriesingerPublished in: Pediatric blood & cancer (2018)
These findings in ST-RELA suggest tumor evasion and immunsuppression due to PD-L1/PD-1-mediated T-cell exhaustion. Trials of checkpoint inhibitors in EPN should be enriched for ST-RELA tumors.