Unspecific binding of cRNA probe to plaques in two mouse models for Alzheimer's disease.
Anne SchaarschuchChristoph RediesNicole Hertelnull nullPublished in: Journal of negative results in biomedicine (2016)
We demonstrate unspecific binding of cRNA probes to plaques in two mouse models for AD. The widespread and general staining of the plaques prevented us from studying endogenous expression of cadherins in transgenic brain by in situ hybridization.