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Leptin administration activates irisin-induced myogenesis via nitric oxide-dependent mechanisms, but reduces its effect on subcutaneous fat browning in mice.

A RodríguezS BecerrilL Méndez-GiménezB RamírezN SáinzV CatalánJavier Gómez-AmbrosiG Frühbeck
Published in: International journal of obesity (2005) (2014)
Taken together, our results provide evidence for a regulatory role of leptin on FNDC5/irisin, favoring muscle accretion but reducing fat browning.
Keyphrases
  • high fat diet induced
  • nitric oxide
  • adipose tissue
  • insulin resistance
  • high glucose
  • skeletal muscle
  • fatty acid
  • transcription factor
  • nitric oxide synthase
  • drug induced
  • metabolic syndrome
  • oxidative stress