Enoxacin Up-Regulates MicroRNA Biogenesis and Down-Regulates Cytotoxic CD8 T-Cell Function in Autoimmune Cholangitis.

Arata ItohDavid AdamsWenting HuangYuehong WuKritika KachapatiKyle J BednarPatrick S C LeungWeici ZhangRichard A FlavellM Eric GershwinWilliam M Ridgway

Published in: Hepatology (Baltimore, Md.) (2021)

Enoxacin increases miRNA expression in dnTGFβRII CD8 T cells, reduces CD8 T-cell pathogenicity, and effectively halted progression of autoimmune biliary disease. Targeting the miRNA pathway is a therapeutic approach to autoimmunity that corrects pathological miRNA abnormalities in autoreactive T cells.

Keyphrases

multiple sclerosis
poor prognosis
cancer therapy
drug induced
binding protein
cystic fibrosis
biofilm formation
pseudomonas aeruginosa
ulcerative colitis