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Insulin-like growth factor 2 (IGF2) expression in adrenocortical disease due to PRKAR1A mutations compared to other benign adrenal tumors.

Kiran S NadellaAnnabel BerthonMadson Q AlmeidaIsaac LevyFabio Rueda FauczConstantine A Stratakis
Published in: Endocrine (2021)
Our data pointed to over-expression of IGF2 protein in PPNAD compared to other benign adrenocortical lesions, such as PMAH and CPA. However, there was no correlation of IGF2 mRNA levels with LOI of IGF2/H19. The discrepancy between mRNA and protein levels with regards to LOI points, perhaps, to different control of IGF2 gene expression in PPNAD.
Keyphrases
  • binding protein
  • growth hormone
  • gene expression
  • pi k akt
  • poor prognosis
  • dna methylation
  • electronic health record
  • big data
  • amino acid