[Aging and growthhormone: assumptions and facts (review of literature).]
S V BulgakovaE V TrenevaN O ZakharovaS G GorelikPublished in: Klinicheskaia laboratornaia diagnostika (2020)
Growth hormone is a powerful metabolic hormone with pleiotropic effects, which is positioned as a "source of youth". Somatotropin has various functions: stimulation of bone growth, regulation of carbohydrate, protein, lipid metabolism, metabolic function of the liver and energy balance. At the cellular level, somatotropic hormone regulates cell growth, differentiation, apoptosis, and cytoskeleton reorganization. The review article presents the results of topical studies that reflect the relationship of growth hormone deficiency or resistance to it with the development of aging and diseases associated with age, as well as with an increase in life expectancy.
Keyphrases
- growth hormone
- oxidative stress
- endoplasmic reticulum stress
- mental health
- physical activity
- bone mineral density
- cell cycle arrest
- young adults
- cell death
- protein protein
- wound healing
- binding protein
- amino acid
- case control
- soft tissue
- fatty acid
- signaling pathway
- body composition
- replacement therapy
- postmenopausal women
- smoking cessation