Randomized trial comparing effects of weight loss by liraglutide with lifestyle modification in non-alcoholic fatty liver disease.
Joan Joo Ching KhooJohn C HsiangRanu TanejaSeok-Hwee KooGaik-Hong SoonCarmen J KamNgai-Moh LawTiing-Leong AngPublished in: Liver international : official journal of the International Association for the Study of the Liver (2019)
Liraglutide was effective for decreasing weight, hepatic steatosis and hepatocellular apoptosis in obese adults with NAFLD, but benefits were not sustained after discontinuation, in contrast with lifestyle modification. Continuing the exercise learned in the structured programme contributed to the maintenance of liver fat reduction.
Keyphrases
- weight loss
- bariatric surgery
- roux en y gastric bypass
- gastric bypass
- physical activity
- oxidative stress
- adipose tissue
- magnetic resonance
- endoplasmic reticulum stress
- high intensity
- cell cycle arrest
- glycemic control
- weight gain
- cell death
- obese patients
- study protocol
- metabolic syndrome
- fatty acid
- type diabetes
- liver fibrosis
- resistance training
- contrast enhanced
- computed tomography
- body mass index
- insulin resistance
- body composition