3-MA has anti-apoptotic and anti-fibrotic effects on the retina of DM mice, and can attenuate retinal oxidative stress, VEGF expression and the production of inflammatory factors in the retina of DM mice. The underlying mechanism of the above effects of 3-MA may be related to its inhibition of early autophagy and hypoglycemic effect.
Keyphrases
- oxidative stress
- cell death
- diabetic retinopathy
- optic nerve
- high fat diet induced
- endoplasmic reticulum stress
- signaling pathway
- poor prognosis
- dna damage
- induced apoptosis
- optical coherence tomography
- diabetic rats
- ischemia reperfusion injury
- endothelial cells
- vascular endothelial growth factor
- glycemic control
- anti inflammatory
- wild type
- type diabetes
- insulin resistance
- idiopathic pulmonary fibrosis
- weight loss
- heat shock
- heat stress