Functional Studies of Anodic Oxidized β-Ti-28Nb-11Ta-8Zr Alloy for Mechanical, In-vitro and Antibacterial Capability.
Hsin-I LinYu-Ming KuoChun-Chih HuMu-Huan LeeLing-Hsiang ChenChung-Tien LiTze-Hong WongTa-Jen YenPublished in: Scientific reports (2018)
We developed an osseocompatible β-type Ti-28Nb-11Ta-8Zr (TNTZ) alloy that displays the excellent elastic modulus, cellular response, corrosion resistance and antibacterial capability demanded for bone-mimetic materials. The TNTZ alloy exhibited an elastic modulus of 49 GPa, which approximates that of human bones and prevent stress shielding effects. A further anodic oxidation and subsequent post-annealing modification formed a crystalline nanoporous TNTZ oxide layer (NPTNTZO(c)) on the alloy surface, potentially promoting interlocking with the extracellular matrix of bone cells and cell proliferation. Osteoblast viability tests also verified that NPTNTZO(c) enhanced cell growth more significantly than that of flat TNTZ. In addition, potentiodynamic polarization tests in Hanks' balanced salt solution (HBSS) revealed that both TNTZ and NPTNTZO(c) exhibited better corrosion resistance than commercial pure titanium. Finally, NPTNTZO(c) reinforced with silver nanoparticles (NPTNTZO
Keyphrases
- silver nanoparticles
- extracellular matrix
- cell proliferation
- bone mineral density
- induced apoptosis
- bone regeneration
- endothelial cells
- pet imaging
- bone loss
- cell cycle arrest
- hydrogen peroxide
- induced pluripotent stem cells
- cell cycle
- signaling pathway
- postmenopausal women
- endoplasmic reticulum stress
- nitric oxide
- room temperature
- pi k akt
- metal organic framework
- pluripotent stem cells
- essential oil
- ionic liquid
- electron transfer
- oxide nanoparticles