Filipino Children with High Usual Vitamin A Intakes and Exposure to Multiple Sources of Vitamin A Have Elevated Total Body Stores of Vitamin A But Do Not Show Clear Evidence of Vitamin A Toxicity.
Reina Engle-StoneJody C MillerMaria Fatima Dolly RearioCharles D ArnoldAme E StormerEleanore LafuenteAnthony OxleyMario V CapanzanaCarl Vincent D CabanillaJennifer Lynn FordAdam ClarkThirumalaisamy P VelavanKenneth H BrownGeorg LietzMarjorie J HaskellPublished in: Current developments in nutrition (2022)
In this sample, most children had retinol intakes above the Tolerable Upper Intake Level (UL) and liver VA concentrations above the proposed cutoff for "hypervitaminosis A" (>1 µmol/g liver). There was no evidence of chronic VA toxicity, suggesting that the liver VA cutoff value should be re-evaluated. This trial was registered at www.clinicaltrials.gov as NCT03030339.