Therapeutic potential of ectopic olfactory and taste receptors.
Sung-Joon LeeInge DepoortereHanns HattPublished in: Nature reviews. Drug discovery (2019)
Olfactory and taste receptors are expressed primarily in the nasal olfactory epithelium and gustatory taste bud cells, where they transmit real-time sensory signals to the brain. However, they are also expressed in multiple extra-nasal and extra-oral tissues, being implicated in diverse biological processes including sperm chemotaxis, muscle regeneration, bronchoconstriction and bronchodilatation, inflammation, appetite regulation and energy metabolism. Elucidation of the physiological roles of these ectopic receptors is revealing potential therapeutic and diagnostic applications in conditions including wounds, hair loss, asthma, obesity and cancers. This Review outlines current understanding of the diverse functions of ectopic olfactory and taste receptors and assesses their potential to be therapeutically exploited.
Keyphrases
- weight loss
- stem cells
- induced apoptosis
- metabolic syndrome
- chronic obstructive pulmonary disease
- skeletal muscle
- insulin resistance
- gene expression
- lung function
- resting state
- body mass index
- multiple sclerosis
- cystic fibrosis
- climate change
- endoplasmic reticulum stress
- cell death
- human health
- high fat diet induced
- functional connectivity
- wound healing
- allergic rhinitis