Atorvastatin reduces β-Adrenergic dysfunction in rats with diabetic cardiomyopathy.

Aude CarillionSarah FeldmanNa NaMatthieu BiaisWassila CarpentierAurélie BirenbaumNicolas CagnardXavier LoyerDominique Bonnefont-RousselotStéphane HatemBruno RiouJulien Amour

Published in: PloS one (2017)

Atorvastatin restored the positive inotropic effect of the β-adrenoceptor stimulation in diabetic cardiomyopathy. This effect is mediated by multiple modifications in expression of proteins in the β-adrenergic signaling pathway, particularly through the NOS pathway.

Keyphrases

signaling pathway
heart failure
type diabetes
wound healing
poor prognosis
pi k akt
oxidative stress
epithelial mesenchymal transition
induced apoptosis
binding protein
nitric oxide synthase
endoplasmic reticulum stress