Login / Signup

Circulating Activated Platelets in Children With Long Covid: A Case-Controlled Preliminary Observation.

Daniele Antonio PizzutoSilvia SorrentinoAntonietta FerrettiRosa MorelloPiero ValentiniLeonardo Di GennaroErica De Candia
Published in: The Pediatric infectious disease journal (2024)
We investigated if children with Long Covid (n=14) have activated platelets compared with healthy controls (n=14). Platelet activation and secretion markers were investigated by flow cytometry using MoAbs directed against P-selectin, CD63, and PAC-1 in quiescent platelets and in platelets stimulated with 10-µM adenosine diphosphate and 25-µM protease activated receptor 1-activating peptide. Circulating platelets of patients with Long Covid had significantly increased expression of the activation marker cytometry using MoAbs directed against P-selectin (P = 0.019).
Keyphrases
  • coronavirus disease
  • sars cov
  • flow cytometry
  • young adults
  • red blood cell
  • poor prognosis
  • respiratory syndrome coronavirus
  • signaling pathway
  • single cell
  • binding protein