Poppers, by Inducing HHV-8 Virion Production, Can Act as a Promoter for HHV-8 Transmission in Men Who Have Sex With Men.

Aude JaryAdélie GothlandRomain PalichValentin LeducqGentiane MonselSébastien ImbertLuminita SchneiderAnne SimonJean-Philippe SpanoChristine KatlamaIslam Amine LarabiJean-Claude AlvarezVincent CalvezAnne-Geneviève Marcelin

Published in: Open forum infectious diseases (2021)

Environmental factors were reported to increase the risk of human herpesvirus 8 (HHV-8) transmission. In a population of men who have sex with men (MSM), we found evidence that chemsex was associated with human herpesvirus 8 seropositivity in vivo and that poppers induced HHV-8 virion production in vitro. Our finding may explain the higher HHV-8 transmission in MSM.

Keyphrases

men who have sex with men
hiv testing
hiv positive

endothelial cells
high glucose
induced pluripotent stem cells

pluripotent stem cells
gene expression
transcription factor

south africa
drug induced