Inhibitory effect of roflumilast on experimental periodontitis.

Qifan LiuYue SunDanying ChenKaidi Chen Baoxin HuangZhuofan Chen

Published in: Journal of periodontology (2021)

PDE4 expression was increased in the gingiva of patients with periodontitis. Roflumilast may decrease alveolar bone loss and the expression of inflammatory cytokines in rats with ligature-induced periodontitis.

Keyphrases

bone loss
poor prognosis
binding protein
long non coding rna
drug induced
endothelial cells