Comparative efficacy and safety of tisagenlecleucel and axicabtagene ciloleucel among adults with r/r follicular lymphoma.

Regulatory approvals of tisagenlecleucel (tisa-cel) and axicabtagene ciloleucel (axi-cel) have established the feasibility of chimeric antigen receptor T-cell therapies for the treatment of adults with relapsed or refractory follicular lymphoma (r/r FL). This study used individual patient data from ELARA (tisa-cel) and aggregate published patient data from ZUMA-5 (axi-cel) to compare efficacy and safety outcomes in r/r FL using matching-adjusted indirect comparison methods. After adjustment for baseline differences in the trial populations, the results suggested that tisa-cel ( n  = 52), compared with axi-cel ( n  = 86), had similar effects on overall response rate (91.2% vs. 94.2%; p  = .58), complete response rate (74.0% vs. 79.1%; p  = .60), progression-free survival (HR [95% CI]: 0.8 [0.4, 1.9]; p  = .67), and overall survival (HR [95% CI]: 0.5 [0.2, 1.5]; p  = .21). Tisa-cel ( n  = 53) was associated with better safety outcomes than axi-cel ( n  = 124), reflected by lower rates of any grade and grade ≥3 cytokine release syndrome and neurological events.