Meta-analysis of microarray data to determine gene indicators involved in the cisplatin resistance in ovarian cancer.
Somayeh Hashemi SheikhshabaniZeinab Amini-FarsaniNesa KazemifardParastoo ModarresZahra Amini-FarsaniMir Davood OmraniSeyedeh Morvarid NeishabouriPublished in: Cancer reports (Hoboken, N.J.) (2023)
Our results predict and suggest that upstream regulators of PI3K/AKT signaling pathway, ion channels, and cell adhesion proteins play important roles in cisplatin resistance development in ovarian cancer.
Keyphrases
- pi k akt
- signaling pathway
- cell adhesion
- systematic review
- cell cycle arrest
- cell proliferation
- induced apoptosis
- meta analyses
- epithelial mesenchymal transition
- electronic health record
- transcription factor
- copy number
- gene expression
- randomized controlled trial
- genome wide
- machine learning
- oxidative stress
- endoplasmic reticulum stress
- genome wide analysis