Prenatal Ethanol Exposure and Postnatal Environmental Intervention Alter Dopaminergic Neuron and Microglia Morphology in the Ventral Tegmental Area During Adulthood.
Claudia I AghaieKathryn A HausknechtRui-Xiang WangParisa Halaji DezfuliSamir Haj-DahmaneCynthia J M KaneWade J SigurdsonRoh-Yu ShenPublished in: Alcoholism, clinical and experimental research (2020)
Our findings show an association between PE-induced morphological activation of microglia and impaired DA neuron morphology in the VTA. Importantly, postnatal environmental intervention rescues possible PE-induced microglial activation. These data support that environmental intervention can be effective in ameliorating cognitive and behavioral deficits associated with VTA DA neuron dysfunctions, such as attention deficits and increased addiction risk.
Keyphrases
- randomized controlled trial
- inflammatory response
- high glucose
- neuropathic pain
- traumatic brain injury
- diabetic rats
- preterm infants
- human health
- spinal cord
- life cycle
- pregnant women
- depressive symptoms
- drug induced
- working memory
- electronic health record
- risk assessment
- lps induced
- machine learning
- deep learning
- early life
- artificial intelligence
- data analysis