Mechanistically informed non-invasive peripheral nerve stimulation for peripheral neuropathic pain: a randomised double-blind sham-controlled trial.

Selina JohnsonAnne MarshallDyfrig HughesEmily HolmesFlorian HenrichTuro NurmikkoManohar SharmaBernhard FrankPaul BassettAndrew MarshallWalter MagerlAndreas Goebel

Published in: Journal of translational medicine (2021)

Results from the RCT failed to reach significance. Results from the mechanistic study provide new evidence for effective induction of LTD in a clinical population. Taken together results add to mechanistic understanding of LTD and help inform future study design and approaches to treatment. Trial registration ISRCTN53432663.

Keyphrases

double blind
neuropathic pain
clinical trial
placebo controlled
study protocol
phase iii
phase ii
spinal cord
open label
spinal cord injury
chemotherapy induced
randomized controlled trial
current status
replacement therapy
smoking cessation