Loss of the adhesion G-protein coupled receptor ADGRF5 in mice induces airway inflammation and the expression of CCL2 in lung endothelial cells.
Fumimasa KuboDonna Maretta AriestantiSouta OkiTaku FukuzawaRyotaro DemizuTomoya SatoRahmaningsih Mara SabirinShigehisa HiroseNobuhiro NakamuraPublished in: Respiratory research (2019)
Targeted disruption of ADGRF5 results in the development of airway inflammation, which is likely mediated by the type 2 immune response and possibly CCL2-mediated inflammation. ADGRF5 also has a potential role in the regulation of genes encoding CCL2 in lung ECs, thereby maintaining immune homeostasis.
Keyphrases
- liver fibrosis
- immune response
- endothelial cells
- liver injury
- poor prognosis
- oxidative stress
- genome wide
- type diabetes
- high fat diet induced
- toll like receptor
- escherichia coli
- dna methylation
- drug delivery
- biofilm formation
- adipose tissue
- cystic fibrosis
- staphylococcus aureus
- long non coding rna
- vascular endothelial growth factor
- bioinformatics analysis