The Impact of Neoadjuvant Chemotherapy on the Surgical Management of Colorectal Peritoneal Metastases: A Systematic Review and Meta-Analysis.
Michael P FloodJoseph C H KongKasmira WilsonHelen MohanPeadar S WatersJacob J McCormickSatish K WarrierJeanne TieRobert RamsayMichael MichaelAlexander G HeriotPublished in: Annals of surgical oncology (2022)
Patients who received neoadjuvant chemotherapy did not experience any increase in perioperative morbidity or mortality. The potential improvement in 5-year overall survival in patients receiving NAC is based on limited confidence due to several limitations in the data, but not sufficiently enough to curtail its use. The practice of NAC in this setting will remain heterogeneous and guided by retrospective evidence until prospective, randomised data are reported.
Keyphrases
- neoadjuvant chemotherapy
- locally advanced
- lymph node
- transcription factor
- sentinel lymph node
- electronic health record
- clinical trial
- big data
- primary care
- cardiac surgery
- rectal cancer
- open label
- squamous cell carcinoma
- cardiovascular events
- data analysis
- randomized controlled trial
- acute kidney injury
- double blind
- coronary artery disease
- risk assessment
- machine learning
- artificial intelligence
- climate change
- deep learning