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Self-Amplifying RNA Vaccine Candidates: Alternative Platforms for mRNA Vaccine Development.

Christin SchmidtBarbara S Schnierle
Published in: Pathogens (Basel, Switzerland) (2023)
The present use of mRNA vaccines against COVID-19 has shown for the first time the potential of mRNA vaccines for infectious diseases. Here we will summarize the current knowledge about improved mRNA vaccines, i.e., the self-amplifying mRNA (saRNA) vaccines. This approach may enhance antigen expression by amplification of the antigen-encoding RNA. RNA design, RNA delivery, and the innate immune responses induced by RNA will be reviewed.
Keyphrases
  • immune response
  • nucleic acid
  • binding protein
  • infectious diseases
  • coronavirus disease
  • poor prognosis
  • toll like receptor
  • inflammatory response
  • label free