Resveratrol protects mitochondrial quantity by activating SIRT1/PGC-1α expression during ovarian hypoxia.

Akemi NishigakiTakeharu KidoNaoko KidaMaiko Kakita-KobayashiHiroaki TsubokuraYoji HisamatsuHidetaka Okada

Published in: Reproductive medicine and biology (2020)

These results suggest that resveratrol improves mitochondrial quantity by activating the SIRT1/PGC-1α pathway and inhibits VEGF induction through HIF-1α under hypoxic conditions.

Keyphrases

oxidative stress
endothelial cells
skeletal muscle
signaling pathway
poor prognosis
ischemia reperfusion injury
vascular endothelial growth factor
binding protein
long non coding rna