The role of platelet-rich plasma in the mild and severe stages of atherosclerotic disease in mice.
Letícia Queiroz da SilvaAmauri da Silva Justo-JuniorBeatriz de Moraes MartinelliMárcio Alves da CruzStephany Cares HuberSilmara Aparecida de Lima MontalvãoLuiz Henrique de Freitas FilhoCristina Pontes VicenteJoyce Maria Annichino-BizzacchiPublished in: Regenerative medicine (2022)
Background: Platelet-rich plasma (PRP) has a high concentration of growth factors (GFs), which present a therapeutic wound healing effect. Despite having been correlated with an immunomodulatory function, the administration of PRP has not yet been investigated in atherosclerosis models. Aim: Evaluate the effect of lyophilized PRP on atherosclerosis in mice models through serum analysis. Methods: Animals received a high-fat diet for disease induction and a weekly PRP retro-orbital application. Effectiveness was evaluated by measuring inflammatory markers in plasma following the treatment of mice with either PRP or saline solution. Results: PRP was well characterized for platelet and GF concentrations; the atherosclerotic profile was established. Cytokine concentrations were altered after PRP applications. Conclusion: PRP could modulate the inflammatory pattern in the early stages of atherosclerosis.