In this article, the decentralized adaptive secure control problem for cyber-physical systems (CPSs) against deception attacks is investigated. The CPSs are formed as a type of nonlinear interconnected strict-feedback systems with uncertain time-varying parameters. The attack affects the information transmission between sensor and actuator in a multiplicative manner. A novel decentralized adaptive backstepping secure control strategy is established by exploiting a particular kind of Nussbaum functions and a flat-zone Lyapunov function analysis approach. It is shown that all of closed-loop signals remain globally bounded, and each output signal eventually converges into a small neighborhood of the origin. Simulation results on an illustrative example are provided to display the effectiveness of the proposed control scheme.