Amelioration of Murine Macrophage Activation Syndrome by Monomethyl Fumarate in Both a Heme Oxygenase 1-Dependent and Heme Oxygenase 1-Independent Manner.
Chhanda BiswasNiansheng ChuThomas N BurnPortia A KreigerEdward M BehrensPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2021)
TLR-9-induced production of IL-10 is regulated by HO-1 activity both in vitro and in vivo. Therapeutic enhancement of the HO-1/IL-10 axis in a murine model was able to significantly ameliorate MAS disease activity. These results suggest that HO-1 may be viable as a MAS therapeutic target, and treatment with DMF and MMF should be considered in future investigations of MAS therapy.
Keyphrases
- disease activity
- rheumatoid arthritis
- systemic lupus erythematosus
- rheumatoid arthritis patients
- ankylosing spondylitis
- pi k akt
- juvenile idiopathic arthritis
- high glucose
- toll like receptor
- inflammatory response
- adipose tissue
- immune response
- case report
- diabetic rats
- current status
- signaling pathway
- stem cells
- drug induced
- stress induced
- nuclear factor