Early-life stress and amyloidosis in mice share pathogenic pathways involving synaptic mitochondria and lipid metabolism.

Janssen M KotahMandy S J KaterNiek BrosensSylvie L LesuisRoberta TandariThomas M BlokLuca MarchettoElla YusafFrank T W KoopmansAugust B SmitPaul J LucassenHarm J KrugersMark H G VerheijenAniko Korosi

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2023)

Our data show that ES and amyloidosis share pathogenic pathways involving synaptic mitochondrial dysfunction and lipid metabolism, which may underlie the observed impact of ES on the trajectory of AD.

Keyphrases

early life
multiple myeloma
prefrontal cortex
fatty acid
electronic health record
cell death
high fat diet induced
big data
reactive oxygen species
type diabetes
machine learning
stress induced
metabolic syndrome